Early menopause/primary ovarian insufficiency – when to consider Fragile X

When to consider Fragile X – Early menopause or primary ovarian insufficiency should trigger genetic testing

Article published in Medical Observer December 2016/January 2017 edition.   Written by Prof Martin Delatycki, Medical Director of Victorian Clinical Genetics Services, with Jean Hailes for Women’s Health, on behalf of Fragile X Association of Australia.

Young women with the FMR1 pre-mutation [ie, young women who are carriers of Fragile X] are at risk of premature ovarian failure.  It is estimated that FXPOI occurs in up to 25% of female carriers of a FMR1 pre-mutation. It can lead to premature menopause, infertility or subfertility, irregular and missed periods, vaginal dryness and insomnia.”

The article is reproduced with the kind permission of Medical Observer.

Attached as pdf here or readable online: http://bit.ly/2gDHwmM





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